rs1048943 in CYP1A1 gene in laryngeal cancer- Sudanese study

Background: The CYP1A1 gene is essential in the metabolism of carcinogenic
polycyclic aromatic hydrocarbons (PAHs). Numerous studies have
investigated the links between the polymorphism Ile462Val rs1048943
A>G and its association with different cancers but the results have
been variable. In this study, we studied rs1048943 in Sudanese patients
diagnosed with laryngeal cancer. Methods: This is a case-control study of
49 laryngeal cancer cases and 50 healthy controls. Restriction fragment
length polymorphisms (RFLP) were used to analyse the fragment region of
the CYP1A1 gene that contains rs1048943. Results: The average age of the
patients was 51.2 years old and the male to female ratio was 1:1.
Well-differentiated squamous cell carcinoma constituted the majority of
the histopathological diagnoses. Ile462Val rs1048943 A>G was not
found in any of the cases but was found in heterozygous form in four
controls (p value 0.1331, OR 0.1044, 95% CI, 0.0054-1.9924). Conclusions:
Our study did not show a significant association of CYP1A1 Ile462Val
rs1048943 A>G with laryngeal cancer. Future studies may need to
test additional single nucleotide polymorphisms (SNPs) in laryngeal cancer
tissue samples to identify the effect of those SNPs on laryngeal cancer.