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siRNA of human CD34+ cells to investigate the role of CD34 antigen in haematopoietic committment

ChEBI2008-06-18 更新2026-07-21 收录

造血干细胞功能

CD34抗原基因沉默

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-8002 数据链接链接失效反馈

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资源简介：

siRNA of human CD34+ cells to investigate the role of CD34 antigen in haematopoietic committment

应用场景：

创建时间：

2008-06-18

造血干细胞功能

Jak-STAT信号通路

Previous studies have illustrated the importance of Jak1-mediated cytokine signaling in immunological and neoplastic diseases such that JAK1 inhibition is currently being investigated in clinical tria

NIAID Data Ecosystem60

The Apcmin mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS. Mus musculus

骨髓增生异常综合征小鼠模型

造血干细胞功能

Apc, a negative regulator of the canonical Wnt signaling pathway, is a bona-fide tumor suppressor whose loss of function results in intestinal polyposis. APC is located in a commonly deleted region on

NIAID Data Ecosystem40

5G2 Mutant Mice Model Loss of a Commonly Deleted Segment of Chromosome 7q22 in Myeloid Malignancies

骨髓增殖性肿瘤遗传学

造血干细胞功能

Monosomy 7 and del(7q) are among the most common and poorly understood genetic alterations in myelodysplastic neoplasms and acute myeloid leukemia. Chromosome band 7q22 is a minimally deleted segment

NIAID Data Ecosystem20

Gene expression profiling in WT and Hif1a-/- HSCs. Mus musculus

造血干细胞功能

基因表达谱分析

To understand the underlying mechanism by which the Hif1a gene is required by hematopoietic stem cells (HSCs), we performed a comparative DNA microarray analysis using total RNA isolated from wild typ

NIAID Data Ecosystem50

STAT1 is essential for hematopoietic stem cell function and maintains a MHC IIhi stem cell subset that resists myeloablation and neoplastic expansion [LK]

造血干细胞功能

STAT1基因

Adult hematopoietic stem cells (HSCs) are predominantly quiescent and can be activated in response to acute stress such as infection or cytotoxic insults. STAT1 is a pivotal mediator of interferon (I

NIAID Data Ecosystem40

siRNA of human CD34+ cells to investigate the role of CD34 antigen in haematopoietic committment

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