single cell analysis of hematopoietic stem/progenitor cells(HSPC) and microenvironmental cells from fetal mouse bone marrow

We use scRNA-seq to analyze HSPC and microenvironmental cells in embryonic mouse bone marrow. The embryonic cells are compared with corresponding cells from Bmx-CreER Wls mice. conditional knockout mice, in which artery derived Wnt secretion is blocked. Overall design: We use single cell RNA-sequencing to analyze the HSPC and microenvironmental cells together in fetal mouse bone marrow.We also analyze Bmx-CreER Wls conditional KO mouse embryos.