Data from: Force and torque on spherical particles in micro-channel flows using computational fluid dynamics|计算流体动力学数据集|微流控数据集

To delineate the influence of hemodynamic force on cell adhesion processes, model in vitro fluidic assays that mimic physiological conditions are commonly employed. Herein, we offer a framework for solution of the 3D Navier-Stokes equations using computational fluid dynamics (CFD) to estimate the forces resulting from fluid flow near a plane acting on a sphere that is either stationary or in free flow, and we compare these results to a widely used theoretical model that assumes Stokes flow with a constant shear rate. We find that while the full 3D solutions using a parabolic velocity profile in CFD simulations yield similar translational velocities to those predicted by the theoretical method, the CFD approach results in ~50% larger rotational velocities over the wall shear stress range of 0.1-5.0 dynes/cm2. This leads to a ~25% difference in force and torque calculations between the two methods. When compared to experimental measurements of translational and rotational velocities of microspheres or cells perfused in microfluidic channels, the CFD simulations yield significantly less error. We propose CFD modeling can provide better estimations of hemodynamic force levels acting on perfused microspheres and cells in flow fields through microfluidic devices utilized for cell adhesion dynamics analysis.