GDF15 reduces NAFLD through mechanisms that are independent of the suppression of food intake. GDF15 reduces NAFLD through mechanisms that are independent of the suppression of food intake

The effects of recombinant human GDF15 and matched caloric restriction in pair-fed controls on obesity and NAFLD in mice fed western diet high in both fat and fructose and housed at thermoneutrality (TN, 29 °C). Overall design: We then performed gene expression profiling analysis using data obtained from liver tissue of mice treated with vehicle, GDF15, or were pair-fed the same weight of food matched to GDF15 treatment group.