Preparation of Laser-Modified Ti-15Mo Surfaces With Multiphase Calcium Phosphate Coatings

Multiphasic bioceramic scaffolds has been enhanced for dental and orthopedic applications. In this perspective, the laser surface texturing of metallic surfaces combined to bioactive calcium phosphate coatings have shown to be promising and economically feasible for biomaterial clinical applications. Ti-15Mo alloy samples were irradiated by pulsed Yb: YAG laser beam. The formation of HA and other calcium phosphates phases by biomimetic method should occur in the presence of Ca2+, PO43-, Mg2+, HCO3-, K+ and Na+. The modified surfaces were submitted to thermal treatment at 380 and 580°C. The results showed the processes of fusion and fast solidification from the laser beam irradiation, inducing the formation of stoichiometric α-Ti, TiO2 and non-stoichiometric titanium oxides, Ti3O and Ti6O with different oxide percentages depending on applied fluency (fluency of 0.023, 0.033, 0.040 and 0.048 J/mm2). The morphological and physicochemical properties have indicated the formation of a multiphase bioceramic coatings. It was observed the formation of amorphous calcium phosphate (ACP), octacalcium phosphate (OCP), and magnesium phosphate (Mg3(PO4)2) phases at 380°C, whereas β-TCP (tricalcium phosphate), OCP, and substituted β-TCP with Ca2,589Mg0,41(PO4)2 were obtained at 580°C. Therefore, the multiphasic bioceramic modified Ti-15Mo surface could enhance osteointegration for bone regeneration.多相生物陶瓷支架（multiphasic bioceramic scaffolds）已针对牙科与骨科应用实现性能优化。在此背景下，金属表面激光纹理化结合生物活性磷酸钙涂层的策略，在生物材料临床应用中展现出良好的应用前景与经济可行性。本研究中，Ti-15Mo合金试样经脉冲Yb:YAG激光束辐照处理。采用仿生法制备羟基磷灰石（HA）及其他磷酸钙相的过程需在Ca²+、PO₄³⁻、Mg²+、HCO₃⁻、K+及Na+的共存体系中进行。将改性后的表面分别置于380℃与580℃下进行热处理。实验结果显示，激光辐照引发的熔融与快速凝固过程，诱导了化学计量比α-Ti、TiO₂以及非化学计量比钛氧化物Ti₃O和Ti₆O的生成，其氧化物占比随施加的辐照能量密度（fluency）变化（辐照能量密度分别为0.023、0.033、0.040及0.048 J/mm²）。形貌与理化性质表征结果证实，成功制备了多相生物陶瓷涂层。在380℃热处理条件下，可观测到无定形磷酸钙（ACP）、磷酸八钙（OCP）及磷酸镁（Mg₃(PO₄)₂）相的生成；而在580℃下则得到β-磷酸三钙（β-TCP，tricalcium phosphate）、OCP以及Ca₂.₅₈₉Mg₀.₄₁(PO₄)₂取代型β-TCP。综上，经多相生物陶瓷改性的Ti-15Mo表面可有效促进骨再生过程中的骨整合。