Potential Role of Inflammation in SARS-CoV-2 Disease Pathology: A multi-omic study in Type II pneumocytes of A/J mice exposed to Lipopolysaccharide

Multi-omic analyses of A/J Type II pneumocytes exposed to lipopolysaccharide were performed to ascertain the similarity of the inflammatory response under these conditions to the inflammatory response seen in SARS-CoV-2 infections. A/J mice were subjected to three weeks of intranasal lipopolysaccharide exposure, after which the Type II pneumocytes were isolated and the mRNA extracted for RNA-Seq analysis