PPARg Deficiency Suppresses the Release of IL-1b and a in Macrophages via a Type 1 Interferon Dependent Mechanism. PPARg Deficiency Suppresses the Release of IL-1b and a in Macrophages via a Type 1 Interferon Dependent Mechanism

TG elicited Peritoneal macrophages from WT and PPARgamma KO mice were treated with control or lipid inflammatory stress in triplicate Overall design: LysM-Cre (cre) controls) or LysM-PPARg (ppar) were treated with vehicle (BSA-PBS; bp) or palmitate (250 uM) with LPS (100 ng/ml); pl for 8h and RNA was extracted