Supplementary Materials.docx

Handgrip strength (HGS) is a crucial indicator of sarcopenia and adverse health outcomes. However, evaluating HGS in children presents challenges, and its association with metabolism remains incompletely understood. This study aimed to establish grip strength reference values for Chinese children and adolescents and assess the role of HGS in relation to cardiometabolic risk. The research successfully established these reference values, introduced the concept of weight-specific HGS and RHGS, and revealed a dose-dependent relationship between weight-specific grip strength and cardiometabolic risk. These findings offer valuable insights into the link between low muscle strength and cardiometabolic risk.

握力（Handgrip strength, HGS）是评估肌少症与不良健康结局的关键指标。然而，儿童群体的握力评估仍存在诸多挑战，且其与代谢状态的关联尚未完全阐明。本研究旨在建立中国儿童青少年的握力参考值，并探讨握力与心血管代谢风险的相关性。本研究成功确立了上述参考值，提出了体重特异性握力（weight-specific HGS）与RHGS的概念，并揭示了体重特异性握力与心血管代谢风险之间的剂量依赖性关联。本研究结果为深入理解肌肉力量低下与心血管代谢风险之间的关联提供了重要参考。