Scoring and ranking of animal models with AD portrait; GFAP mutation differential gene expression results.

Scoring and ranking of over 500 models are compared with the AD portrait based on a hypergeometric test. Highest positive score represents the highest model match. Genes in the same direction are rewarded in scoring while genes in the opposite direction are penalized. Analysis also allows for identification of models that are most discordant with AD where patterns of genes are in the opposite direction. Differential gene expression of hippocampus and corpus collosum comparing GFAP mutation mouse model with control.
(XLSX)