Summary findings of integrative omic analysis of endoxifen sensitivity in HapMap YRI LCLs.

Six steps of associations among endoxifen sensitivity, SNP genotype, mRNA and miRNA expressions were conducted sequentially for 4 endoxifen treatment concentrations independently. Step 1, the association between the phenotypes of endoxifen sensitivity and ∼13,000 gene/transcript cluster expressions; step 2, the association between the phenotypes of endoxifen sensitivity and 201 miRNA expressions; step 3, the negative correlation between mRNA and miRNA expressions from step 1 and step 2; step 4, the association between mRNA expressions from step 3 and SNP genotypes; step 5, the association between miRNA expression from step 3 and SNP genotypes from step 4; step 6, the association of SNP genotypes from step 5 and the phenotypes of endoxifen sensitivity. The final associations are the SNP genotypes, mRNA and miRNA expressions from the step 6 that correlate with endoxifen sensitivity but also associate each other. Numbers of identified biomarkers were indicated in each step for each phenotype. “3, 5, 7 and 10 μM” represent phenotypes of the 4 concentrations of endoxifen treatment. “Pheno” represents the phenotypes of endoxifen sensitivity.