Data_Sheet_1_Non-pharmacological interventions for behavioral and psychological symptoms of dementia: A systematic review and network meta-analysis protocol.doc

IntroductionDementia patients often experience behavioral and psychological symptoms (BPSD), which severely affect their quality of life and activities of daily living. Non-pharmacological interventions are effective in treating BPSD, according to multiple clinical trials and systematic reviews. However, the optimal non-pharmacological treatment remains controversial. Therefore, the study aims to evaluate and compare multiple non-pharmacological methods for treating BPSD in order to identify the optimal non-pharmacological intervention.ObjectiveThis study aims to perform a systematic review and network meta-analysis of evidence on non-pharmacological interventions in the treatment of BPSD, which may potentially guide future research and clinical decisions.MethodsIn order to select potentially relevant randomized controlled trials (RCTs), 10 academic databases and 3 clinical trial registries will be systematically searched from inception until the 1 October 2022. Two researchers will independently extract information from eligible articles. The primary outcome is the severity of BPSD. Herein, Pairwise and Bayesian network meta-analyses will be conducted utilizing STATA 15.0 and ADDIS 1.16.8. Evidence quality will be assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE).ResultsResults from this study will be published in peer-reviewed journals or conference reports.DiscussionIn this study, we aim to comparatively assess the efficacy of various non-pharmacological treatments for BPSD. Findings from this review will help clinicians to make evidence-based treatment decisions.Systematic review registration[https://www.crd.york.ac.uk/prospero/], identifier [CRD42022352095].

引言：痴呆症患者常常遭受行为和心理症状（BPSD），这些症状严重影响了他们的生活质量及日常生活活动。根据多项临床试验和系统评价，非药物治疗在治疗BPSD方面是有效的。然而，关于最佳非药物治疗方案仍存在争议。因此，本研究旨在评估和比较多种非药物治疗BPSD的方法，以确定最佳的非药物治疗干预措施。目标：本研究旨在对治疗BPSD的非药物治疗证据进行系统评价和网络Meta分析，这或许能指导未来的研究和临床决策。方法：为了选择可能相关的随机对照试验（RCTs），将从创立之初至2022年10月1日系统地检索10个学术数据库和3个临床试验注册库。两位研究人员将独立地从符合条件的研究文章中提取信息。主要结局指标是BPSD的严重程度。在此，将利用STATA 15.0和ADDIS 1.16.8进行成对和贝叶斯网络Meta分析。将使用分级推荐评估、发展和评价（GRADE）方法评估证据质量。结果：本研究的结果将在同行评审的期刊或会议报告中发表。讨论：本研究旨在比较评估各种非药物治疗BPSD的疗效。该综述的发现将有助于临床医生做出基于证据的治疗决策。系统评价注册[https://www.crd.york.ac.uk/prospero/]，标识符[CRD42022352095]。