CPD-seq mapping of UV damage formation and repair in yeast

UV-induced DNA lesions are an important contributor to mutagenesis and cancer, but it is not fully understood how the chromosomal landscape influences UV lesion formation and repair紫外线（UV）诱导的DNA损伤是诱变作用与癌症发生的重要诱因，但目前学界尚未完全明晰染色体景观（chromosomal landscape）如何影响紫外线损伤的形成与修复过程。