Effectiveness of Fluorescein-based Multispectral Smart Endoscopy for Detecting Colorectal Neoplasia

Interventions: Drug : 1. WLE-Fluorescence Group
?Insert colonoscopy with a transparent distal attachment under white light endoscopy (WLE).
?Intravenous administration of fluorescein sodium 1 ampule (10%, 5 mL) after cecal intubation
?WLE examination from cecum to hepatic flexure and record lesions detected.
?Insert colonoscopy under WLE up to cecum and then fluorescence endoscopic examination from cecum to hepatic flexure. Record and remove lesions detected.
?WLE examination from transverse colon to splenic flexure and record lesions detected.
?Insert colonoscopy under WLE up to hepatic flexure and then fluorescence endoscopic examination from transverse colon to splenic flexure. Record and remove lesions detected.
?WLE examination from descending colon to rectum and record lesions detected.
?Insert colonoscopy under WLE up to descending colon and then fluorescence endoscopic examination from descending colon to rectum. Record and remove lesions detected.
2. Fluorescence-WLE Group
?Insert colonoscopy with a transparent distal attachment under white light endoscopy (WLE).
?Intravenous administration of fluorescein sodium 1 ampule (10%, 5 mL) after cecal intubation
?Fluorescence endoscopic examination from cecum to hepatic flexure and record the lesions detected
?Insert colonoscopy under WLE up to cecum and then WLE examination from cecum to hepatic flexure. Record and remove the lesions detected.
?Fluorescence endoscopic examination from transverse colon to splenic flexure and record the lesions detected
?Insert colonoscopy under WLE up to hepatic flexure and then WLE examination from transverse colon to splenic flexure. Record and remove lesions detected.
?Fluorescence endoscopic examination from descending colon to r
Primary outcome(s): Number of fluorescence positive polyps
Primary Purpose : Diagnosis, Intervention Model : Cross-over, Blinding/Masking : Open, Allocation : RCT