Crystal structure of pregnane X receptor ligand binding domain in complex with SJPYT-310
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Crystal structure of pregnane X receptor ligand binding domain in complex with SJPYT-310 Descriptor: (1P)-N-(5-tert-butyl-2-{[(2S)-pentan-2-yl]oxy}phenyl)-1-(2-methoxy-5-methylphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide, DIMETHYL SULFOXIDE, Pregnane X receptor ligand binding domain fused to SRC-1 coactivator peptide Authors: Garcia-Maldonado, E, Huber, A.D, Nithianantham, S, Miller, D.J, Chen, T. Deposit date: 2023-05-17 Release date: 2024-05-15 Last modified: 2024-05-29 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR. Nat Commun, 15, 2024
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2023-05-17
