Drug2Gene

We have built Drug2Gene, a knowledge base, which combines the compound/drug-gene/protein information from 19 publicly available databases. A key feature is our rigorous unification and standardization process which makes the data truly comparable on a large scale, allowing for the first time effective data mining in such a large knowledge corpus. As of version 3.2, Drug2Gene contains 4,372,290 unified relations between compounds and their targets most of which include reported bioactivity data. We extend this set with putative (i.e. homology-inferred) relations where sufficient sequence homology between proteins suggests they may bind to similar compounds. Drug2Gene provides powerful search functionalities, very flexible export procedures, and a user-friendly web interface.

搜集汇总

背景与挑战

背景概述

Drug2Gene是一个整合了19个公开数据库的药物-基因关系知识库，通过严格的标准化过程实现大规模数据可比性，包含超过437万条统一关系和生物活性数据，并提供搜索、导出和用户界面功能。该数据集支持药物发现和生物信息学领域的研究。