Lactobacillus rhamnosus strains relieve loperamide-induced constipation via different pathways

A close association has been identified between the gut microbiota and human health. Many studies have confirmed an imbalance in the faecal flora of patients with slow transit constipation. Although several population and animal experiments have identified probiotics as effective for the relief of constipation symptoms, the specific mechanism remains unclear. In this study, Lactobacillus rhamnosus strains isolated from five different sources were administered as interventions to mice with loperamide-induced constipation, and the effects of these strains on constipation-related indicators were evaluated. Notably, all five strains of L. rhamnosus alleviated constipation-related symptoms, and all were associated with different levels of gastrointestinal regulatory peptides, neurotransmitters and neurotrophic factors and the composition of the gut microbiota in mice with constipation?