Targeting TRIM21-PD-1 axis potentiates immune checkpoint blockade and CAR T cell therapy
收藏国家人口健康科学数据中心2026-06-01 收录
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https://www.ncmi.cn/phda/dataDetails.do?id=CSTR:17970.11.A001G.202502.160.V1.0
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资源简介：
TRIM21 catalyzes K63-linked ubiquitination of PD-1, stabilizing it by counteracting K48-linked ubiquitination and degradation. TRIM21 knockout reduces PD-1 levels, activates CD8+ T cells, enhances tumor sensitivity to anti-CTLA-4 therapy, and improves the anti-tumor efficacy of anti-CD19 CAR T cells.
提供机构：
北京蛋白质组研究中心
创建时间：
2024-12-03
