Novel Alzheimer risk genes determine the microglia response to amyloid-β but not to TAU pathology. Novel Alzheimer risk genes determine the microglia response to amyloid-β but not to TAU pathology

胶质细胞转录组学

Polygenic risk scores have identified that genetic variants without genome-wide significance still add to the genetic risk of developing Alzheimer’s disease (AD). Whether and how subthreshold risk loc

NIAID Data Ecosystem40

Hydroxyurea attenuates oxidative, metabolic, and excitotoxic stress in rat hippocampal neurons and improves spatial memory in a mouse model of Alzheimer’s disease. Hydroxyurea attenuates oxidative, metabolic, and excitotoxic stress in rat hippocampal neurons and improves spatial memory in a mouse model of Alzheimer’s disease

阿尔茨海默病干预

神经元保护

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

NIAID Data Ecosystem20

AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation

阿尔茨海默病机制

胶质细胞调控

The hemizygous R47H variant of TREM2, a microglia-specific gene in the brain, increases risk for late-onset Alzheimer's disease (AD). Using transcriptomic analysis at the single-nuclei level from brai

NIAID Data Ecosystem10