Involvement of Microglia-Expressed MS4A6A in the Onset of Glioblastoma(Raw Data)

Glioblastoma multiforme (GBM) represents the deadliest form of brain tumor, characterized by its low survival rate and grim prognosis. Cytokines released from glioma-associated microglia/macrophages are involving in establishing tumor microenvironment, thereby crucially promoting GBM progression.<i> MS4A6A</i> polymorphism was confirmed to be associated with neurodegenerative and polymorphisms disease pathobiology, but whether it participates in the regulation of GBM and the underlying mechanisms are still not elucidated. Here, we found that MS4A6A was significantly upregulated in GBM patient samples. The results from single-cell RNA-sequencing (scRNA-seq) database and immunostaining demonstrated the specific expression of MS4A6A in microglial cells. In vitro, microglial overexpression of MS4A6A stimulated the proliferation and migration of glioblastoma cells. Moreover, high<i> MS4A6A </i>mRNA expression was related with poor prognosis in GBM patients. Our study highlights the potential of MS4A6A as a promising biomarker for GBM, which may provide novel strategies for its prevention, diagnosis and treatment.