Long-term health outcomes among CNS HAND Study cohort

The CNS HAND study was primarily conducted among 254 people living with HIV (PLHIV) and 72 HIV-negative persons from a primary care clinic in Sydney, Australia named Holdsworth House General Practice to assess the burden of HIV-associated neurocognitive disorder (HAND) among PLHIV and to validate the CogState computerized cognitive screening tool for the diagnosis of HAND. This baseline study took place between October 2011 and October 2012. Exclusion criteria at the entry of the study was alcohol or substance intoxication. Providing that majority of the study participants continue receiving care at the clinic, their long-term health outcome data on age-related non-AIDS conditions (major neurological and cognitive disorders, cardiovascular diseases, diabetes, osteoporosis, non-AIDS cancers, and chronic kidney, liver and lung diseases) were collected in June 2021 censoring the study end point at the end of April 2021. Three HIV-negative participants were excluded from this long-term outcome study because of seroconversion during the study follow-up period. This deidentified individual participant dataset was used for survival analyses to identify if PLHIV despite under suppressive combination antiretroviral therapy has higher risks for age-related non-AIDS conditions compared to age and lifestyle-matched HIV-negative persons.

中枢神经系统HIV相关神经认知障碍研究（CNS HAND study）最初在澳大利亚悉尼的霍兹沃思全科诊所（Holdsworth House General Practice）开展，共纳入254名艾滋病病毒感染者（People Living with HIV, PLHIV）及72名艾滋病病毒阴性对照受试者，旨在评估艾滋病病毒感染者群体中HIV相关神经认知障碍（HIV-associated neurocognitive disorder, HAND）的疾病负担，并验证CogState计算机化认知筛查工具用于HAND诊断的诊断效能。本基线研究于2011年10月至2012年10月期间进行。研究入组的排除标准为酒精或物质中毒。鉴于多数研究受试者仍在该诊所接受诊疗，研究团队于2021年6月收集了他们的长期健康结局数据，所关注的年龄相关性非艾滋病病症包括：主要神经与认知障碍、心血管疾病、糖尿病、骨质疏松症、非艾滋病相关癌症，以及慢性肾脏、肝脏与肺部疾病，本研究的终点截尾至2021年4月末。另有3名艾滋病病毒阴性对照受试者因在研究随访期间发生血清转换，被排除出本次长期结局研究。本去标识化的个体受试者数据集被用于生存分析，以探究在接受抑制性联合抗反转录病毒治疗的前提下，艾滋病病毒感染者相较于年龄与生活方式匹配的艾滋病病毒阴性对照受试者，是否存在更高的年龄相关性非艾滋病病症患病风险。