CircAkt3 participates in bone cancer pain progression in rats by modulating MAPK signalling pathway

CircRNA parent genes were mainly enriched in MAPK and neurodevelopmental signalling pathways. CircAkt3 and circMap4k1 were significantly up-regulated in the BCP group. CircaAkt3 may increase p-ERK expression by upregulating Col8a1, which may further activate the MAPK pathway.环状RNA（CircRNA）的亲本基因主要富集于丝裂原活化蛋白激酶（MAPK）信号通路与神经发育信号通路中。circAkt3与circMap4k1在BCP组中显著上调。CircaAkt3可通过上调Col8a1的表达，提升p-ERK的表达水平，进而进一步激活MAPK信号通路。