probiotics mixture alleviates atopic dermatitis in mice

Atopic dermatitis (AD) is a recurrent chronic inflammatory skin disease affecting up to 30% of the children population, and immuno-regulatory therapy that could modify the course of the disease is urgently needed. Probiotics have demonstrated therapeutic effects on AD and could potentially regulate the disease process. However, the efficacy of probiotics for AD is inconsistent among different studies, which is mainly due to the elusive mechanism and different species and (or) strains used. In this study, We found that IW5 significantly alleviated skin inflammation of the MC903-induced AD in mice. We also found that the diversity of the gut microbiota in the mice with MC903-induced dermatitis was increased after oral administration of probiotics.