Gut microbiome analysis between different responsiveness to EPO of hemodialysis patients with anemia

EPO hyporesponsiveness in hemodialysis patients is still unclear. We analysis gut microbiota between different responsiveness to EPO in hemodialysis patients with anemia using 16s rDNA sequencing. The poor-responsivenes s(PR) patients displayed a characteristic composition of the gut microbiome that clearly differed from that of good-responsiveness (GR) patients. 9 genera (Neisseria, Streptococcus, Porphyromonas, Fusobacterium, Prevotella_7, Rothia, Leptotrichia, Prevotella, Actinomyces) we identified could excellently predict EPO hyporesponsiveness. In contrast, 5 genera (Faecalibacterium, Citrobacter, Bifidobacterium, Escherichia-Shigella, Bacteroides) identified present a good protective effect against EPO hyporesponsiveness.