Transcriptomic characterization of control and drug-treated APOB-mutant organoids to study steatosis-resolving drug effects
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https://www.ncbi.nlm.nih.gov/sra/SRP414695
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资源简介：
We treated APOB-mutant organoids with different anti-NAFLD drug candidates that were effective at resolving steatosis. To understand the mechanisms of drug action and adverse drug effects we performed bulk RNA-sequencing on drug-treated and vehicle-treated APOB mutant organoids. Overall design: APOB-mutant organoids, 2 clonal lines from 2 different donors, were treated with the respective drug (ACCi, FASi, DGAT2i, FXRa, or hFGF19) or vehicle (control) for 7 days. Thereafter, organoids were harvested for RNA extraction.
创建时间：
2023-06-02
