Imaging data for: Arp2/3 involvement in intercellular bridge membrane fluctuations and constriction during neural stem cell divisions
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https://datadryad.org/dataset/doi:10.5061/dryad.tmpg4f5d1
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资源简介:
This dataset contains imaging data of Drosophila neural stem cells within
larval brains, capturing cellular morphology and spatial organization. It
accompanies the study “Arp2/3 involvement in intercellular bridge membrane
fluctuations and constriction during neural stem cell divisions,” which
investigates the mechanisms of intercellular bridge (ICB) remodeling
during the final stages of neural stem cell division in the Drosophila
larval brain. Unlike ICBs in cultured cells, which have flanking regions
that thin as sibling cells move apart, neural stem cell ICBs lack flanking
arms and constrict primarily at the midbody. Using super-resolution,
full-volume live imaging, the study revealed dynamic plasma membrane
fluctuations surrounding the ICB. Inhibition of the Arp2/3 complex, a key
nucleator of branched actin filaments, reduced these fluctuations and
impaired ICB thinning. These findings suggest that dynamic branched actin
networks contribute to ICB membrane remodeling and help support
constriction of the intercellular bridge during neural stem cell division.
These data may be reused for image analysis, quantitative reanalysis, or
methodological development. Users are expected to cite both this dataset
and the associated publication in any use, presentation, or derivative
work. While the data are publicly available, users are encouraged to
contact the dataset authors for clarification, guidance, or collaboration.
提供机构:
Dryad
创建时间:
2026-03-14



