Divergent Total Synthesis of Triptolide, Triptonide, Tripdiolide, 16-Hydroxytriptolide, and Their Analogues
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https://figshare.com/articles/dataset/Divergent_Total_Synthesis_of_Triptolide_Triptonide_Tripdiolide_16_Hydroxytriptolide_and_Their_Analogues/2237581
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资源简介：
A divergent route was developed for the formal total synthesis
of triptolide, triptonide, and tripdiolide, as well as a total synthesis
of 16-hydroxytriptolide and their analogues in an enantioselective
form. Common advanced intermediate 5 was concisely assembled
by employing an indium(III)-catalyzed cationic polycyclization
reaction and a palladium-catalyzed carbonylation–lactone formation
reaction as key steps. This advanced intermediate was readily converted
to the above natural products by using palladium-catalyzed cross-coupling
or the Claisen rearrangement reaction as key steps. Additionally,
preliminary structure–cytotoxic activity relationship studies
of C13 suggested that it might be a new modification site that could
still retain the cytotoxicity.
创建时间：
2016-02-16
