Synthesis and Antifungal Activity of Novel Quinazolin-4(3<i>H</i>)-one Derivatives

A novel group of 6-iodoquinazolin-4(<i>3H</i>)-one derivatives was prepared starting from 6-iodo-2-ethoxy-4<i>H</i>-3,1-benzoxazin-4-one <b>(3)</b> via action of various nitrogen nucleophiles such as primary and secondary amines, hydrazine hydrate, and its derivatives. The 3-amino-2-hydrazinyl-6-iodoquinazolin-4(<i>3H</i>)-one <b>(15)</b> was used as a key starting material to prepare new heterocyclic compounds. The structures of all synthesized compounds were inferred from the infrared, mass spectral, and ¹H NMR spectral data as well as elemental analysis. The fungicidal activities of the target compounds were preliminarily evaluated.本研究以6-碘-2-乙氧基-4H-3,1-苯并噁嗪-4-酮(3)为起始原料，通过伯胺、仲胺、水合肼及其衍生物等多种氮亲核试剂的作用，制备了一系列新型6-碘喹唑啉-4(3H)-酮衍生物。其中3-氨基-2-肼基-6-碘喹唑啉-4(3H)-酮(15)作为关键起始原料，用于合成新型杂环化合物。所有合成化合物的结构均通过红外光谱、质谱、核磁共振氢谱（¹H NMR）数据及元素分析得以推导确认。本研究对目标化合物的杀菌活性进行了初步评价。