Transcriptomic study of NR8383 cells following exposure to zinc oxide nanoparticles NM110

To identify differentially expressed genes and key biological pathways that define toxicity following nanoparticle exposure, we performed microarray analyses on NR8383 macrophages exposed for 4 h to 2 µg/mL of NP ZnO (20 % cell viability). This project (SmartNanoTox) has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 686098.为筛选可表征纳米颗粒暴露后毒性效应的差异表达基因与关键生物学通路，我们对暴露于2 µg/mL氧化锌纳米颗粒（NP ZnO）、处理时长4小时且细胞存活率为20%的NR8383巨噬细胞开展了基因芯片分析。本项目（SmartNanoTox）获欧盟“地平线2020”研究与创新计划资助，资助协议编号为686098。