WP430 - Statin inhibition of cholesterol production - Homo sapiens
收藏NIAID Data Ecosystem2026-05-02 收录
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资源简介：
Statins inhibit endogenous cholesterol production by competitive inhibition of HMG-CoA reductase (HMGCR), the enzyme that catalyzes conversion of HMG-CoA to mevalonate, an early rate-limiting step in cholesterol synthesis. This pathway delineates genes involved in statin pharmacogenomics, including genes involved in mediating the effects of statins on plasma lipoprotein metabolism.
Sources: [PharmGKB](https://www.pharmgkb.org/pathway/PA2031) and [Wikipedia](http://en.wikipedia.org/wiki/Statin)
Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP430).
创建时间：
2025-04-17
