Effect of obesity genetic risk scores on standardized and non-standardized adipocyte area in μm2 in different fat depots.

Estimates derived from a linear regression model with estimates of adipocyte area in μm2 per 1-unit higher genetic risk score, corresponding to a predicted 1 standard deviation higher obesity trait and adjusting for 10 principal components in all cohorts. In GTEx, fatDIVA and MOBB, adjustments were also made for age and sex, and with and without adjusting for BMI. In the all-female ENDOX cohort, adjustments were made for 10 principal components and with and without adjusting for chip type as the other covariates were unavailable. In the main meta-analysis model (assuming a fixed-effect model), ENDOX was included adjusted for chip type. Two sensitivity meta-analyses were performed; including ENDOX unadjusted for chip type and excluding the ENDOX cohort. (XLSX)