Additional file 1 of Genetic crossroads of cardiovascular disease and its comorbidities: toward holistic therapeutic strategies

Supplementary Material 1: Table S1: List of 19 diseases including cardiovascular diseasesand their comorbidities and their definitions. Table S2: Percentage of sample overlap between FinnGen genome-wide association studiesof the 19 diseases. Table S3: Statistical significanceof the genetic correlation among the 19 cardiovascular diseases and their comorbidities as estimated using Linkage disequilibrium scoreregression. Table S4: Summary of 29 SNPs identified from multitrait GWAS via GenomicSEM, including original GWAS betas, standard errors, p-values, alternate allele frequency, alternate allele frequency among cases, alternate allele frequency among controlsand Q-SNP heterogeneity statistics. Table S5: Standardized factor loadings and standard errors for individual traits in the GenomicSEM model of the genetic latent factor. Table S6: Previously reported GWAS associations for 29 independent SNPs supporting external validity of multivariate GWAS findings.