Predicted R-loops specifically detected in 3T3 and E14 were generated by selecting genome bins that were assigned probabilities ≥ 0.9 when applied one cell line model and ≤ 0.1 when applied the other.
Kethoxal-assisted ssDNA sequencing (KAS-seq) is gaining popularity as a robust and effective approach to study the dynamics of transcriptionally engaged RNA polymerases through profiling of genome-wid
The R-loop, composed of a DNA-RNA hybrid and the displaced single-stranded DNA, regulates diverse cellular processes. However, how cellular R-loops are sensed remain poorly understood. Here we report
