Sertoli cell specific testicular gene expression of Connexin 43 knockout mice

Infertility observed in adult Sertoli cell (SC)-specific Connexin 43 Knockout-mice rather seems to be an effect of the disturbed SC-Germ cell (GC) crosstalk than a direct consequence of the loss of Cx43 protein in SC with important GC specific genes being mostly affected by this deletion. Identification of differentially expressed genes in testis of cx43 KO-mice at developmental stage 8 days post partum when compared with testis of WT-mice成年支持细胞（Sertoli cell, SC）特异性连接蛋白43（Connexin 43, Cx43）基因敲除小鼠所呈现的不育表型，更倾向于由支持细胞-生殖细胞（SC-Germ cell, GC）信号串扰紊乱所介导，而非支持细胞内Cx43蛋白缺失的直接结果；该基因敲除事件会显著影响诸多生殖细胞特异性基因的表达。本数据集旨在对产后8天发育阶段的Cx43基因敲除小鼠睾丸与野生型（WT）小鼠睾丸中的差异表达基因（differentially expressed genes）进行鉴定分析。