Metastasis-specific gene expression in autochthonous and allograft mouse mammary tumor models: stratification and identification of targetable signatures

Transcriptomic study of metastases generated by many of the most widely used mouse models of breast cancer metastasis Paired primary tumor and metastatic tissues were collected from several mouse models of metastatic breast cancer. RNA sequencing was then performed in order to characterize the differences between metastasis-specific gene expression in different models, and also to identify shared metastasis-specific transcriptomic characteristics.