A Phase III Trial Evaluating the Addition of Trastuzumab to Trimodality Treatment of HER2-Overexpressing Esophageal Adenocarcinoma

This randomized phase III trial studies how well radiation therapy, paclitaxel, and
carboplatin with or without trastuzumab work in treating patients with esophageal cancer.
Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy,
such as paclitaxel and carboplatin, work in different ways to stop the growth of tumor cells,
either by killing the cells, by stopping them from dividing, or by stopping them from
spreading. Monoclonal antibodies, such as trastuzumab, may interfere with the ability of
tumor cells to grow and spread. It is not yet known whether giving radiation therapy and
combination chemotherapy together with or without trastuzumab is more effective in treating
esophageal cancer.