EED inhibitor impedes dendritic cell inflammatory functions

Dendritic cells (DCs), the main antigen-presenting cells, are at the forefront of the immunity in response to autoimmune diseases. Epigenetic histone H3 lysine K27 trimethylation (H3K27me3) modification by embryonic ectoderm development (EED) is tightly associated with restrained transcriptional programs and has important functions in diverse biological processes and diseases, but its role in DC functionality remains elusive. In this study, we show that EED inhibitors block the activation especially migration of DCs, thus emphasizing EED as a pivotal regulator in DC homeostasis, which may be of great value for autoimmune disorders. Overall design: LPS and LPS+EED inhibitor treated DC2.4