Treponema_Pallidum_genomic_diversity_within_and_between_patients_in_Ghana

Yaws, caused by the bacterium Treponema pallidum subspecies pertenue (TPE), is the target of a current WHO eradication campaign, but the global prevalence and genomic diversity is still poorly understood. TPE sequencing frequently utilises targetted sequencing methods directly from clinical samples, and these data inherently contain information on within-sample diversity. In this study conducted in Ghana, we prospectively collected longitudinally sampled TPE positive swabs from different lesions on the same patients to allow robust analysis and validation of diversity within and between patients.