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Dicer and Hsp104 function in a negative feedback loop to confer epigenetic robustness

ChEBI2015-04-23 更新2026-07-21 收录

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蛋白质功能互作

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-60640 数据链接链接失效反馈

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Dicer and Hsp104 function in a negative feedback loop to confer epigenetic robustness

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创建时间：

2015-04-23

R-loop研究

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Strand asymmetry in the distribution of guanines and cytosines, measured by GC skew, predisposes DNA sequences towards R-loop formation upon transcription. Previous work revealed that GC skew and R-lo

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DNMT3A Reads and Connects Histone H3K36me2 to DNA methylation [RNA-seq]

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DNA methylation at the 5-position of cytosine (5mC) is a crucial epigenetic mark in regulating biological processes including gene silencing, gene imprinting, and X chromosome inactivation. It has lon

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Stage-specific Kdm6b-transcription factor partnerships orchestrate temporal precision during stepwise motor neuron differentiation [RNA-seq]

运动神经元

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Histone modifiers instruct cellular differentiation, yet how they achieve temporal precision remains enigmatic. Here we demonstrate that the H3K27 demethylase Kdm6b acts as a master epigenetic conduct

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DNA dioxygenases Tet2/3 control epithelial differentiation [RNA-seq]

毛囊上皮分化

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Execution of lineage-specific differentiation programs requires tight coordination between many regulators including Ten-eleven translocation (TET) family enzymes catalyzing 5-methylcytosine oxidation

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To investigate whether the expression of upregulated genes in hdc1 and hda19 is assoiated with histone acetylation levels increased in the hdc1 and hda19 mutants, We carried out ChIP-seq to examine hi

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Dicer and Hsp104 function in a negative feedback loop to confer epigenetic robustness

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