Differential microRNA expressions during development of mouse cornea

Expression of microRNAs (miRNA) was examined in the wild type mouse cornea at postnatal day 9 (PN9) before stratification of the corneal epithelium and at 6 weeks of age when the epithelium is fully stratified. Using Sanger miRBase Version 10.0, we analysed 568 miRNAs across 4 biological replicates of the developing (PN9) and mature (6-week-old) mouse cornea.本研究检测了野生型小鼠角膜在出生后第9天（PN9，此时角膜上皮尚未发生分层）以及6周龄（此时角膜上皮已完全分层）时的微小核糖核酸（microRNAs, miRNA）表达水平。研究采用桑格miRBase数据库版本10.0，对发育阶段（PN9）与成熟阶段（6周龄）的小鼠角膜的4个生物学重复样本中的568个微小核糖核酸进行了分析。