Data from: Multivariate analysis of electrophysiological diversity of Xenopus visual neurons during development and plasticity

Biophysical properties of neurons become increasingly diverse over
development, but mechanisms underlying and constraining this diversity are
not fully understood. Here we investigate electrophysiological
characteristics of Xenopus tadpole midbrain neurons across development and
during homeostatic plasticity induced by patterned visual stimulation. We
show that in development tectal neuron properties not only change on
average, but also become increasingly diverse. After sensory stimulation,
both electrophysiological diversity and functional differentiation of
cells are reduced. At the same time, the amount of cross-correlations
between cell properties increase after patterned stimulation as a result
of homeostatic plasticity. We show that tectal neurons with similar
spiking profiles often have strikingly different electrophysiological
properties, and demonstrate that changes in intrinsic excitability during
development and in response to sensory stimulation are mediated by
different underlying mechanisms. Overall, this analysis and the
accompanying dataset provide a unique framework for further studies of
network maturation in Xenopus tadpoles.