Natural resistance to lenacapavir and fostemsavir investigated by ultra-deep sequencing of near full-length HIV-1 genomes

This study aimed to detect the presence of amino acid variants related to lenacapavir (LEN) and fostemsavir (FTR) genotypic resistance in the viral quasispecies of antiretroviral naive primary HIV infections sustained by different HIV-1 subtypes and circulating recombinant forms (CRFs).