Data associated with "Site-specific Raman Probes Reveal Droplet Aging and Residue-level Fibril Polymorphism in TDP-43CTD"
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Images in Data Folder Figure 1B 1h: Widefield fluorescence image of thioflavin-T-stained TDP-43CTD droplets 1 hour after droplet formation. Figure 1B 95h: Widefield fluorescence image of thioflavin-T-stained TDP-43CTD droplets 95 hours after droplet formation. Figure 1C 1h: Bright field image of TDP-43CTD droplets 1 hour after droplet formation. Figure 1C 48h droplets: Bright field image of TDP-43CTD droplets 48 hours after droplet formation. Figure 1C 48h fibrils: Bright field image of TDP-43CTD fibrils 48 hours after droplet formation. Figure 2O 283: Bright field image of F283FCC-TDP-43CTD fibrils 48 hours after droplet formation. Figure 2O 313: Bright field image of F313FCC-TDP-43CTD fibrils 48 hours after droplet formation. Figure 2O 334: Bright field image of W334FCC-TDP-43CTD fibrils 48 hours after droplet formation. Figure 2O 367: Bright field image of F367FCC-TDP-43CTD fibrils 48 hours after droplet formation. Figure 2O 374 P1: Bright field image of Y374FCC-TDP-43CTD polymorph P1 fibrils 48 hours after droplet formation. Figure 2O 374 P2: Bright field image of Y374FCC-TDP-43CTD polymorph P2 fibrils 48 hours after droplet formation. Figure 2O 385 P1: Bright field image of W385FCC-TDP-43CTD polymorph P1 fibrils 48 hours after droplet formation. Figure 2O 385 P2: Bright field image of W385FCC-TDP-43CTD polymorph P2 fibrils 48 hours after droplet formation. Figure 2O 385 P3: Bright field image of W385FCC-TDP-43CTD polymorph P3 fibrils 48 hours after droplet formation. Figure 2O 397 P1: Bright field image of F397FCC-TDP-43CTD polymorph P1 fibrils 48 hours after droplet formation. Figure 2O 397 P2: Bright field image of F397FCC-TDP-43CTD polymorph P2 fibrils 48 hours after droplet formation. Figure 2O WT: Bright field image of WT-TDP-43CTD fibrils 48 hours after droplet formation. Figure 2P Inset 24h: Bright field image of W334FCC-TDP-43CTD droplets and fibrils 24 hours after droplet formation. Figure 2P Inset 25h: Bright field image of W334FCC-TDP-43CTD droplets and fibrils 25 hours after droplet formation. Figure 2P Inset 26h: Bright field image of W334FCC-TDP-43CTD droplets and fibrils 26 hours after droplet formation. Images Figure S1: Transmission electron micrograph of WT-TDP-43CTD fibrils. Source Data for Main Text and Supporting Information Raman data: Full Raman spectra and difference spectra of WT and FCC mutants of TDP-43CTD in the droplet and fibril states taken at various time points. Full Raman spectra for N-acetyl-4-ethynyl-l-phenylalanine methyl ester in various solvents. Raman shift values have been corrected using the spectrum of neat cyclohexane.
