RNA sequencing analysis of WT- and Tet2-/-G17VRHOA-CD4 splenocytes
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https://www.ncbi.nlm.nih.gov/sra/SRP246817
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资源简介：
Angioimmunoblastic T-cell lymphoma, a subtype of T-cell lymphoma, is a disease with relative poor outcome. Genetic analysis in human samples showed the co-existence of common mutations in TET2 and RHOA genes. We have made a mouse model resembling the genetic lesions in human AITL. Our mice developed AITL-like lymphoma after 40 weeks old. We analyzed the expression of transcriptomes in WT- and Tet2-/-G17VRHOA-CD4 splenocytes to find out the underlying pathogenesis mechanism of AITL. Overall design: We examine 4 mice of WT group and 3 mice of Tet2-/-G17VRHOA group.
创建时间：
2020-05-07
