Mass cytometry data of mouse AML treated with IMPDH inhibitor FF-10501-01

NIAID Data Ecosystem2026-03-14 收录

白血病耐药机制

质谱流式细胞分析

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资源简介：

Mass cytometry data of MLL-AF9 leukemia cells treated with vehicle or IMPDH inhibitor FF-10501-01.

创建时间：

2022-09-30

Dasatinib Resistant K562 cell lines

白血病耐药机制

酪氨酸激酶抑制剂

A project to explore the acquisition of drug resistance mechanisms in a K562 erythroblastic leukemia cell line, with induced resistance to the tyrosine kinase inhibitor, dasatinib. Cells were exposed

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AML Relapse After BET Inhibition and Chemotherapy Is Characterized by Myc-Ras Transcriptional Remodeling

白血病耐药机制

染色质重塑靶向治疗

Genome-wide analysis of adult and pediatric acute myeloid leukemias (AMLs) revealed distinct mutational profiles characterized by a higher incidence of RAS mutations in young patients. Here we show th

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Table S3 from Single-Cell Lineage Tracing Uncovers Resistance Signatures and Sensitizing Strategies to FLT3 Inhibitors in Acute Myeloid Leukemia

白血病耐药机制

FLT3抑制剂基因表达

Table S3 shows quizartinib pre-resistance gene expression signatures.

NIAID Data Ecosystem10

RNA-Sequencing and targeted exome sequencing of venetoclax resistant human leukemia from spleens and bone-marrow of patient-derived xenograft models

白血病耐药机制

药物基因组学

For RNAseq, mRNA was extracted from spleen and bone marrow of venetoclax resistant and matched parental PDX leukemia cells using RNeasy kit (Qiagen). Non-stranded RNA-seq libraries were generated usin

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Acquired MEN1 mutations mediate resistance to Menin inhibition [RNA-seq]. Acquired MEN1 mutations mediate resistance to Menin inhibition [RNA-seq]

白血病耐药机制

MLL1

Acute leukemias driven by rearrangements of the Mixed Lineage Leukemia gene (MLLr) or mutants of Nucleophosmin (NPM1c) require the chromatin adapter protein Menin, encoded by the MEN1 gene, to sustain

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Mass cytometry data of mouse AML treated with IMPDH inhibitor FF-10501-01

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