Trigeminal nerve derived-substance P regulates biological characteristics of limbal stem cells through PI3K-AKT signaling pathway
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE213140
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资源简介：
To investigate the function of Substance P- NK1R interaction in the regulation of limbal stem cells, we subconjunctivally injected NK1 receptor antagonist L-733,060 on mice. By RNA sequencing, we found that antagonist injection significantly downregulated PI3K-AKT signaling related genes level. Collectively, our work reveals that Substance P- NK1R interaction is a novel player in limbal stem cells regulation. Comparative gene expression profiling analysis of RNA-seq data for antagonist- injected and control mice limbus.
创建时间：
2023-05-17
