CRK binds BCAR1 and or PXN

CRK (CT10 Regulator of Kinase) is composed of one SH2 and one or two SH3 domains. This adaptor protein binds with phosphorylated tyrosine motifs found in proteins involved in cell spreading, actin reorganisation, and cell migration. Paxillin (PAX) and p130CAS are the two major focal adhesion components that binds with CRK to form multiprotein signaling complexes and regulate cell migration (Klemke et al. 1998, Valles et al. 2004, Lamorte et al. 2003).

CRK（CT10激酶调节因子）由一个SH2和一个或两个SH3结构域组成。此适配蛋白与参与细胞扩展、肌动蛋白重组和细胞迁移的蛋白质中发现的磷酸化酪氨酸基序相结合。Paxillin（PAX）和p130CAS是两种主要的焦点粘附成分，它们与CRK结合，形成多蛋白信号复合物，并调节细胞迁移（Klemke等，1998年，Valles等，2004年，Lamorte等，2003年）。