Inhibitory effects against SARS-COV-2 main protease of terpenic substances and selenated naphthoquinones
收藏Taylor & Francis Group2025-09-21 更新2026-04-16 收录
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https://tandf.figshare.com/articles/dataset/Inhibitory_effects_against_SARS-COV-2_main_protease_of_terpenic_substances_and_selenated_naphthoquinones/30174019/1
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资源简介：
Clinical studies on COVID-19 patients revealed among multiple symptoms, uncontrolled production of inflammatory mediators. The current study presents the inhibitory effects of eleven terpenoid derivatives (<b>1–11</b>) and two naphthoquinones (<b>12</b> and <b>13</b>) on the main protease (Mpro) of SARS-CoV-2. All the terpenoids and compound <b>13</b> displayed weak inhibitory effects while compound <b>12</b> showed moderate inhibitory effects of M<sup>pro</sup> with IC<sub>50</sub> of 50.2 µM. Anti-inflammatory effects against pro-inflammatory mediators produced in LPS-induced lung injury and the cytotoxicity against Vero and THP-1 cell lines of molecules <b>12</b> and <b>13</b> were also evaluated. Molecules <b>12</b> and <b>13</b> presented promising anti-inflammatory activity by attenuating the exudation and neutrophil and leukocyte migration.
提供机构：
da Silva Júnior, Eufrânio N.; de Oliveira, Paula G. F.; de Assis, Francisco F.; Scotti, Marcus T.; Dambrós, Bibiana P.; Souza, Gabriella B.; Buss, Ziliani S.; Beck, Bianca K.; Scheide, Marcos R.; Lubschinski, Tainá L.; Sandjo, Louis P.; Steindel, Mario; Braga, Antonio L.; Dalmarco, Eduardo M.; Tizziani, Tiago
创建时间：
2025-09-21
