Homo sapiens Transcriptome

Mesenchymal stem cells (MSCs) have demonstrated remarkable therapeuticpromise for acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS). MSC secretomes contain various immunoregulatory mediators that modulate both innate and adaptive immune responses. Priming MSCs has been widely considered to boost their therapeutic efficacy for a variety of diseases. Prostaglandin E2 (PGE2) plays a vital role in physiological processes that mediate the regeneration of injured organs. This work utilized PGE2 to prime MSCs and investigated their therapeutic potential in ALI models.