CDK5:p25 phosphorylates PRDX1

Oxidative stress, manifested through accumulation of reactive oxygen species in the cell, is one of the hallmarks of Alzheimer's disease. Based on mouse model studies, CDK5, aberrantly activated by binding to p25, phosphorylates the peroxide reductase PRDX1 on a conserved threonine residue T90, thus inactivating it and contributing to ROS accumulation (Sun et al. 2008).

氧化应激，表现为细胞内活性氧物质的累积，是阿尔茨海默病的显著特征之一。基于小鼠模型研究，CDK5在p25的结合下异常激活，在保守的苏氨酸残基T90上磷酸化过氧化物还原酶PRDX1，从而使其失活并导致活性氧的积累（Sun等，2008年）。